Abstract: A one-pot, single-step, and an atom-economical process towards the synthesis of highly\nfunctionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical\nyields (70â??93%) with excellent relative diastereo-, and regio-selectivity. An in vitro antiproliferative\nassay was carried out on different cancer cell lines to evaluate the biological activity of the synthesized\ntetrahydro-1â??H-spiro[indoline-3,5â??-pyrrolo[1,2-c]thiazol]-2-one 5aâ??n. The prepared hybrids were\nthen tested in vitro for their antiproliferative effects against three cancer cell lines, namely, HepG2\n(liver cancer), MCF-7 (breast cancer), and HCT-116 (colon cancer). The spirooxindole analogue 5g\nexhibited a broad activity against HepG2, MCF-7, and HCT-116 cell lines of liver, breast, and colorectal\ncancers when compared to cisplatin. Modeling studies including shape similarity, lipophilicity scores,\nand physicochemical parameters were calculated. The results of this study indicated that spirooxindole\nanalogue 5g retained a good physiochemical parameters with acceptable lipophilicity scores.
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